Development and validation of a clinical prediction rule for development of diabetic foot ulceration:
an analysis of data from five cohort studies. - Chappell, Francesca M., et al., 2021
The paper outlines the development and validation of a clinical prediction rule for foot ulceration in people
living with diabetes. 8,255 cases were used for the development of the risk assessment tool and 3,324 cases
were used to validate it. This resulted in a 5 point scoring system that predicts the risk of developing a foot
ulcer with good accuracy.
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Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis.
- Margolis, D. J., Kantor, J., & Berlin, J. A., 1999
This meta study systematically reviewed of 10 research papers
with the aim of ascertaining the healing percentage of neuropathic diabetic foot ulcers when receiving standard
quality wound care within a specified time frame. The results revealed that after 12 weeks only around 24% of
ulcers healed and after 20 weeks still only 31% ulcers heal. These long healing times
demonstrate the urgent need to prevent ulcer formation in the first place.
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Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational
study. - Vadiveloo, Thenmalar, et al., 2018
This research studied amputation-free survival rates among individuals
with diabetes at high risk for foot ulceration, categorising them based on their ulceration status: no previous ulcer,
active ulcer, or healed previous ulcer. The study found that individuals with healed ulcers had higher death rates,
but those with active ulcers had the highest risk of amputation, emphasising the critical need for early intervention
and management in high-risk individuals.
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Long Term Prognosis After Healed Amputation in Patients With Diabetes.
- Larsson, Jan, et al., 1998
This prospective study explored outcomes such as mortality, rehabilitation,
and recurrence of amputations in diabetic patients post-healing of an initial amputation, categorising them based on the
extent of the initial amputation. The results showed a significant difference in mortality rates and rehabilitation
potential between minor and major amputations, with major amputations showing higher mortality and lower rehabilitation
potential. Notably, 85% of new amputations were precipitated by a foot ulcer, emphasising the importance of meticulous
foot care and monitoring in diabetic patients.
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Assessment of Signs of Foot Infection in Diabetes Patients Using Photographic Foot Imaging and Infrared Thermography.
- Hazenberg C.E., et al., 2014
This paper inspired the use of combined thermal and visible light imaging
in Podium. It concludes that the diagnosis of foot infection in patients living with diabetes seems valid and reliable
when using photographic imaging in combination with infrared thermography in at-home monitoring of high-risk patients to
facilitate early diagnosis of signs of foot infection.
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The cost of diabetic foot ulcers and amputations to the National Health Service in England.
- Kerr, M., et al., 2019
This research aimed to quantify the healthcare costs associated with diabetic
foot disease in England, focusing on the financial burden of foot ulceration and amputation. The study revealed that the healthcare
costs related to diabetic foot disease are substantial, estimated between £837 million and £962 million annually, constituting
a significant proportion of the National Health Service (NHS) budget for England. The majority of this expenditure is attributed
to ulceration, with potential substantial savings if the prevalence of diabetic foot ulcers is reduced, emphasising the critical
need for effective prevention and management strategies. Infrared thermography in at-home monitoring of high-risk patients to
facilitate early diagnosis of signs of foot infection.
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Diabetic foot ulcer management in clinical practice in the UK: costs and outcomes.
- Guest, J. F., Fuller, G. W., & Vowden, P., 2018
This study analysed diabetic foot ulcer (DFU) management within the UK's NHS,
revealing predominant community management with minimal specialist involvement. It uncovered inefficient care, with only 35% of
DFUs healing within 12 months and 17% undergoing amputation within the first 12 months. The mean NHS cost per DFU over 12 months
was £7,800. The study highlighted the potential benefits of strategies focusing on wound prevention, improved wound-healing, and
reduced infection and amputation rates for both patients and the NHS.
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